Trailing by a goal from last week's first leg, Freiburg aim to overturn their deficit and reach the Europa League quarter-finals on Thursday, when they host fallen giants Juventus.
Juve are more accustomed to life among Europe's elite, but having established a lead to take to Germany, they will now try to finish the job in their last-16 tie
Seeking a memorable fightback if they are to reach the Europa League quarter-finals, Real Sociedad welcome Roma to Anoeta on Thursday, in the second leg of their last-16 tie.
Following a chaotic and unpredictable 2-2 draw in the first leg of their Europa League last-16 tie, Arsenal and Sporting Lisbon reconvene at the Emirates for Thursday's decisive encounter.
Real Betis have a mountain to climb if they're to progress to the quarter-finals of the UEFA Europa League (UEL) after a thumping 4-1 defeat in the first leg gave a huge advantage to visitors Manchester United.
Aiming to leave domestic troubles behind and take a step closer to some silverware, Juventus host Bundesliga upstarts Freiburg on Thursday night, in the Europa League's last 16.
With nightmares of their Anfield mauling still fresh in the memory, Manchester United return to Europa League action with the visit of Real Betis to Old Trafford for the first leg of their last-16 tie on Thursday night.
Resuming their quest for an elusive continental crown, Arsenal travel to the Estadio Jose Alvalade XXI for the first leg of their Europa League last-16 clash with Sporting Lisbon on Thursday night
Manchester United's 19 goals scored by substitutes in all competitions this season is the most of any big five European league side in 2022-23
A spot in the last 16 of the Europa League will be on the line Thursday when Monaco host Bayer Leverkusen at Stade Louis II.
Juventus travel to the Stade de la Beaujoire to face Nantes in the second leg of their playoff